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Chip-based waveguides for high-sensitivity biosensing and super-resolution imaging Review Articles

Chen-lei Pang, Xu Liu, Wei Chen, Qing Yang,qingyang@zju.edu.cn

Frontiers of Information Technology & Electronic Engineering 2020, Volume 21, Issue 8,   Pages 1134-1149 doi: 10.1631/FITEE.1900211

Abstract: In this review, we introduce some chip-based waveguide biosensing and imaging techniques, which significantly reduce the complexity of the entire system. These techniques use a well-confined evanescent field to interact with the surrounding materials and achieve high sensitivity sensing and high signal-to-noise ratio (SNR) super-resolution imaging. The fabrication process of these chips is simple and compatible with conventional semiconductor fabrication methods, allowing high-yield production. Combined with recently developed chip-based light sources, these techniques offer the possibility of biosensing and super-resolution imaging based on integrated circuits.

Keywords： Waveguide-based sensing     Waveguide-based imaging     Evanescent illumination     Frequency shifting and stitching    

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A general method of designing phase-shifting algorithms for grating lateral shearing interferometry None

Chao FANG, Yang XIANG, Ke-qi QI

Frontiers of Information Technology & Electronic Engineering 2018, Volume 19, Issue 6,   Pages 809-814 doi: 10.1631/FITEE.1601692

Abstract: We propose a general method of designing phase-shifting algorithms for grating lateral shearing interferometryThe algorithms compensate for the zeroth-order effect error and phase-shifting error in varying degreesWe derive a general expression of the phase-shifting algorithm in grating lateral shearing interferometerBased on the expression and method, four phase-shifting algorithms are designed with different phase-shiftingA new 13-frame phase-shifting algorithm is designed and simulated with a large zeroth-order effect.

Keywords： Interferometry     Phase measurement     Phase-shifting algorithms    

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Novel decoupled framework for reliability-based design optimization of structures using a robust shifting

Mohammad Reza GHASEMI, Charles V. CAMP, Babak DIZANGIAN

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 4,   Pages 800-820 doi: 10.1007/s11709-019-0517-7

Abstract: In a reliability-based design optimization (RBDO), computation of the failure probability ( ) at all design points through the process may suitably be avoided at the early stages. Thus, to reduce extensive computations of RBDO, one could decouple the optimization and reliability analysis. The present work proposes a new methodology for such a decoupled approach that separates optimization and reliability analysis into two procedures which significantly improve the computational efficiency of the RBDO. This technique is based on the probabilistic sensitivity approach (PSA) on the shifted probability density function. Stochastic variables are separated into two groups of desired and non-desired variables. The three-phase procedure may be summarized as: Phase 1, apply deterministic design optimization based on mean values of random variables; Phase 2, move designs toward a reliable space using PSA and finding a primary reliable optimum point; Phase 3, applying an intelligent self-adaptive procedure based on cubic B-spline interpolation functions until the targeted failure probability is reached. An improved response surface method is used for computation of failure probability. The proposed RBDO approach could significantly reduce the number of analyses required to less than 10% of conventional methods. The computational efficacy of this approach is demonstrated by solving four benchmark truss design problems published in the structural optimization literature.

Keywords： reliability-based design optimization     trusses     sensitivity analysis     shifting technique     cubic B-splines    

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SHIFTING TO A RECOMMENDED DIETARY PATTERN COULD PROMOTE SUSTAINABLE DEVELOPMENT OF THE ENVIRONMENT AND

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 1,   Pages 73-82 doi: 10.15302/J-FASE-2023489

Abstract:

● Shifting from the existing dietary patterns to the alternative

Keywords： CHNS data     cluster analysis     dietary patterns     sustainable development    

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A frequency error estimation for isogeometric analysis of Kirchhoff–Love cylindrical shells

Frontiers of Structural and Civil Engineering doi: 10.1007/s11709-023-0006-x

Abstract: A frequency error estimation is presented for the isogeometric free vibration analysis of Kirchhoff–LoveBy analyzing the discrete isogeometric equations with the aid of harmonic wave assumption, the frequencyIn particular, the governing relationship of the continuum frequency for Kirchhoff–Love cylindrical shellsis naturally embedded into the frequency error measures without the need of explicit frequency expressionsNumerical results not only thoroughly verify the theoretical convergence rates of frequency solutions

Keywords： isogeometric analysis     Kirchhoff–Love cylindrical shell     free vibration     frequency error     convergence    

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Development of surface reconstruction algorithms for optical interferometric measurement

Dongxu WU, Fengzhou FANG

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 1,   Pages 1-31 doi: 10.1007/s11465-020-0602-6

Abstract: background and recent advances of fringe analysis algorithms, including coherence peak sensing and phase-shiftingTo address these challenges, advanced techniques in image stitching, on-machine measurement, intelligent

Keywords： surface topography     measurement     optical interferometry     coherence envelope     phase-shifting algorithm    

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Calculation of collision frequency function for aerosol particles in free molecule regime in presence

Xiaowei LUO, Yannick BENICHOU, Suyuan YU

Frontiers in Energy 2013, Volume 7, Issue 4,   Pages 506-510 doi: 10.1007/s11708-013-0275-5

Abstract: The collision frequency function for aerosol particles has already been calculated for the free moleculeforce, electric force and molecular forces, created by particles themselves, recalculated the collision frequencyAttractive forces increase naturally the collision frequency, while repulsive forces decrease it.

Keywords： aerosol particles     collision frequency function     coagulation    

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Fuel variability effect on flickering frequency of diffusion flames

Jizhao LI, Yang ZHANG

Frontiers in Energy 2009, Volume 3, Issue 2,   Pages 134-140 doi: 10.1007/s11708-009-0034-9

Abstract: The intent of this study is to investigate the fuel variability on the flickering frequency of diffusionIt was found that the low frequency oscillation of flow and flame structures depended only weakly onWhen a mixture of methane/propane at a ratio of 1:1 was used the peak flickering frequency was aroundMechanisms thought to produce changes in the dynamic response and frequency harmonics were discussed.

Keywords： fuel variability     flickering frequency     diffusion flames     dynamics of combustion    

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Capacity limitation of nuclear units in grid based on analysis of frequency regulation

Yiping DAI, Pan JIANG, Lin GAO, Weimin KAN, Xiaoqing XIAO, Ge JIN

Frontiers in Energy 2012, Volume 6, Issue 2,   Pages 148-154 doi: 10.1007/s11708-012-0174-1

Abstract: Based on the analysis of frequency regulation, mathematic models for nuclear units in the grid are establishedThe relationship between different styles of frequency regulation and the allowable capacity of the nuclear

Keywords： nuclear units capacity     overspeed     primary frequency control (PFC)     second frequency control (SFC)    

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Oscillation frequency of simplified arterial tubes

Hui AN, Fan HE, Lingxia XING, Xiaoyang LI

Frontiers of Mechanical Engineering 2009, Volume 4, Issue 3,   Pages 300-304 doi: 10.1007/s11465-009-0038-5

Abstract: To construct the spatial kinetic equation of an arterial tube and obtain its radial natural frequencyThe results show that the first-order frequency is 15.8 Hz and the obtained exact analytical solutions

Keywords： spatial kinematics     natural frequency     finite element method    

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Parameter identification of interconnected power system frequency after trip-out of high voltage transmission

Xuzhan ZHOU,Shanshan LIU,Mingkun WANG,Yiping DAI,Yaohua TANG

Frontiers in Energy 2014, Volume 8, Issue 3,   Pages 386-393 doi: 10.1007/s11708-014-0323-9

Abstract: Accurate modeling and parameters of high voltage (HV) grid are critical for stability research of system frequencyIn this paper, simulation modeling of the system frequency was conducted of an interconnected power system

Keywords： high voltage (HV) grid     frequency stability parameter identification     primary frequency regulation (PFR    

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Dependence of error sensitivity of frequency on bias voltage in force-balanced micro accelerometer

Lili CHEN, Wu ZHOU

Frontiers of Mechanical Engineering 2013, Volume 8, Issue 2,   Pages 146-149 doi: 10.1007/s11465-013-0260-z

Abstract:

To predict more precisely the frequency of force-balanced micro accelerometer with different biasvoltages, the effects of bias voltages on error sensitivity of frequency is studied.The resonance frequency of accelerometer under closed loop control is derived according to its operationsensitivity with designed parameters of structure, circuit and process error can be used to predict the frequency

Keywords： Micro-Electro-Mechanical Systems (MEMS)     micro accelerometer     force-balanced micro accelerometer     frequency    

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Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 493-502 doi: 10.1007/s11684-022-0946-x

Abstract: Anaplastic lymphoma kinase (ALK) is the most common fusion gene involved in non-small cell lung cancer (NSCLC), and remarkable response has been achieved with the use of ALK tyrosine kinase inhibitors (ALK-TKIs). However, the clinical efficacy is highly variable. Pre-existing intratumoral heterogeneity (ITH) has been proven to contribute to the poor treatment response and the resistance to targeted therapies. In this work, we investigated whether the variant allele frequencies (VAFs) of ALK fusions can help assess ITH and predict targeted therapy efficacy. Through the application of next-generation sequencing (NGS), 7.2% (326/4548) of patients were detected to be ALK positive. On the basis of the adjusted VAF (adjVAF, VAF normalization for tumor purity) of four different threshold values (adjVAF < 50%, 40%, 30%, or 20%), the association of ALK subclonality with crizotinib efficacy was assessed. Nonetheless, no statistical association was observed between median progression-free survival (PFS) and ALK subclonality assessed by adjVAF, and a poor correlation of adjVAF with PFS was found among the 85 patients who received first-line crizotinib. Results suggest that the ALK VAF determined by hybrid capture-based NGS is probably unreliable for ITH assessment and targeted therapy efficacy prediction in NSCLC.

Keywords： next-generation sequencing     fluorescence in situ hybridization     immunohistochemistry     variant allele frequency    

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Remote calibration system for frequency based on in-place benchmark

Xiaobin HONG, Guixiong LIU, Zhuokui WU, Xipeng DU,

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 3,   Pages 316-321 doi: 10.1007/s11465-010-0021-1

Abstract: calibration mode based on material object reference, a new model of a remote calibration system for frequencysome key problems for the remote calibration system is particularly discussed, including the time and frequencybenchmark receiving module based on global positioning system (GPS), frequency comparison based on aphase method, frequency division based on dual high-frequency phase locked loop (PLL), and remote calibration

Keywords： remote calibration     in-place benchmark     frequency comparison     global position system (GPS)    

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Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness

Wenjun Xia,Fei Liu,Duan Ma

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 137-142 doi: 10.1007/s11684-016-0449-8

Abstract: On the basis of the frequency of hearing loss, hereditary non-syndromic hearing loss can be divided intohigh-, mid-, low-, and total-frequency hearing loss.Up to now, merely 7 loci have been linked to mid-frequency hearing loss.Only four genetic mid-frequency deafness genes, namely, DFNA10 (EYA4), DFNA8/12 (TECTA)This review summarizes the research progress of the four genes to draw attention to mid-frequency deafness

Keywords： hereditary non-syndromic hearing loss     mid-frequency hearing loss     deafness genes    

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Title Author Date Type Operation

Chip-based waveguides for high-sensitivity biosensing and super-resolution imaging

Chen-lei Pang, Xu Liu, Wei Chen, Qing Yang,qingyang@zju.edu.cn

Journal Article

A general method of designing phase-shifting algorithms for grating lateral shearing interferometry

Chao FANG, Yang XIANG, Ke-qi QI

Journal Article

Novel decoupled framework for reliability-based design optimization of structures using a robust shifting

Mohammad Reza GHASEMI, Charles V. CAMP, Babak DIZANGIAN

Journal Article

SHIFTING TO A RECOMMENDED DIETARY PATTERN COULD PROMOTE SUSTAINABLE DEVELOPMENT OF THE ENVIRONMENT AND

Journal Article

A frequency error estimation for isogeometric analysis of Kirchhoff–Love cylindrical shells

Journal Article

Development of surface reconstruction algorithms for optical interferometric measurement

Dongxu WU, Fengzhou FANG

Journal Article

Calculation of collision frequency function for aerosol particles in free molecule regime in presence

Xiaowei LUO, Yannick BENICHOU, Suyuan YU

Journal Article

Fuel variability effect on flickering frequency of diffusion flames

Jizhao LI, Yang ZHANG

Journal Article

Capacity limitation of nuclear units in grid based on analysis of frequency regulation

Yiping DAI, Pan JIANG, Lin GAO, Weimin KAN, Xiaoqing XIAO, Ge JIN

Journal Article

Oscillation frequency of simplified arterial tubes

Hui AN, Fan HE, Lingxia XING, Xiaoyang LI

Journal Article

Parameter identification of interconnected power system frequency after trip-out of high voltage transmission

Xuzhan ZHOU,Shanshan LIU,Mingkun WANG,Yiping DAI,Yaohua TANG

Journal Article

Dependence of error sensitivity of frequency on bias voltage in force-balanced micro accelerometer

Lili CHEN, Wu ZHOU

Journal Article

Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy

Journal Article

Remote calibration system for frequency based on in-place benchmark

Xiaobin HONG, Guixiong LIU, Zhuokui WU, Xipeng DU,

Journal Article

Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness

Wenjun Xia,Fei Liu,Duan Ma

Journal Article